The Darwin <literal>stdenv</literal> uses clang instead of gcc. When referring to the compiler <varname>$CC</varname> or <command>cc</command> will work in both cases. Some builds hardcode gcc/g++ in their build scripts, that can usually be fixed with using something like <literal>makeFlags = [ "CC=cc" ];</literal> or by patching the build scripts.
On Darwin, libraries are linked using absolute paths, libraries are resolved by their <literal>install_name</literal> at link time. Sometimes packages won't set this correctly causing the library lookups to fail at runtime. This can be fixed by adding extra linker flags or by running <command>install_name_tool -id</command> during the <function>fixupPhase</function>.
Even if the libraries are linked using absolute paths and resolved via their <literal>install_name</literal> correctly, tests can sometimes fail to run binaries. This happens because the <varname>checkPhase</varname> runs before the libraries are installed.
This can usually be solved by running the tests after the <varname>installPhase</varname> or alternatively by using <varname>DYLD_LIBRARY_PATH</varname>. More information about this variable can be found in the <citerefentry>
Some packages assume xcode is available and use <command>xcrun</command> to resolve build tools like <command>clang</command>, etc. This causes errors like <code>xcode-select: error: no developer tools were found at '/Applications/Xcode.app'</code> while the build doesn't actually depend on xcode.
The package <literal>xcbuild</literal> can be used to build projects that really depend on Xcode. However, this replacement is not 100% compatible with Xcode and can occasionally cause issues.