diff --git a/pkgs/development/interpreters/python/2.7/default.nix b/pkgs/development/interpreters/python/2.7/default.nix
index 6f951bc28370..e08fde3c8bfc 100644
--- a/pkgs/development/interpreters/python/2.7/default.nix
+++ b/pkgs/development/interpreters/python/2.7/default.nix
@@ -68,6 +68,8 @@ let
       done
     '' + optionalString stdenv.isDarwin ''
       substituteInPlace configure --replace '`/usr/bin/arch`' '"i386"'
+      substituteInPlace Lib/multiprocessing/__init__.py \
+        --replace 'os.popen(comm)' 'os.popen("nproc")'
     '';
 
   configureFlags = [
@@ -95,11 +97,7 @@ let
         ] ++ optionals x11Support [ tcl tk xlibsWrapper libX11 ]
     )
     ++ optional zlibSupport zlib
-
-    # depend on CF and configd only if purity is an issue
-    # the impure bootstrap compiler can't build CoreFoundation currently. it requires
-    # <mach-o/dyld.h> which is in our pure bootstrapTools, but not in the system headers.
-    ++ optionals (stdenv.isDarwin && !stdenv.cc.nativeLibc) [ CF configd ];
+    ++ optionals stdenv.isDarwin [ CF configd ];
 
   # Build the basic Python interpreter without modules that have
   # external dependencies.
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index ed71333eb3de..f6ad5d2a8974 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -5677,6 +5677,9 @@ let
 
     propagatedBuildInputs = with self; [ argh pathtools pyyaml ];
 
+    buildInputs = stdenv.lib.optionals stdenv.isDarwin
+      [ pkgs.darwin.apple_sdk.frameworks.CoreServices pkgs.darwin.cf-private ];
+
     doCheck = false;
 
     src = pkgs.fetchurl {
@@ -11836,6 +11839,11 @@ let
       substituteInPlace setup.py \
         --replace "['pandas/src/klib', 'pandas/src']" \
                   "['pandas/src/klib', 'pandas/src', '$cpp_sdk']"
+
+      # disable clipboard tests since pbcopy/pbpaste are not open source
+      substituteInPlace pandas/io/tests/test_clipboard.py \
+        --replace pandas.util.clipboard no_such_module \
+        --replace OSError ImportError
     '';
 
     # The flag `-A 'not network'` will disable tests that use internet.