diff --git a/pkgs/desktops/gnome/misc/nautilus-python/default.nix b/pkgs/desktops/gnome/misc/nautilus-python/default.nix
index 40c1d4c767af..ed1fd365ebc6 100644
--- a/pkgs/desktops/gnome/misc/nautilus-python/default.nix
+++ b/pkgs/desktops/gnome/misc/nautilus-python/default.nix
@@ -1,4 +1,6 @@
-{ lib, stdenv
+{ stdenv
+, lib
+, substituteAll
 , fetchurl
 , pkg-config
 , which
@@ -23,6 +25,16 @@ stdenv.mkDerivation rec {
     sha256 = "161050sx3sdxqcpjkjcpf6wl4kx0jydihga7mcvrj9c2f8ly0g07";
   };
 
+  patches = [
+    # Make PyGObject’s gi library available.
+    (substituteAll {
+      src = ./fix-paths.patch;
+      pythonPaths = lib.concatMapStringsSep ", " (pkg: "'${pkg}/${python3.sitePackages}'") [
+        python3.pkgs.pygobject3
+      ];
+    })
+  ];
+
   nativeBuildInputs = [
     pkg-config
     which
diff --git a/pkgs/desktops/gnome/misc/nautilus-python/fix-paths.patch b/pkgs/desktops/gnome/misc/nautilus-python/fix-paths.patch
new file mode 100644
index 000000000000..ba82937d6c9c
--- /dev/null
+++ b/pkgs/desktops/gnome/misc/nautilus-python/fix-paths.patch
@@ -0,0 +1,14 @@
+diff --git a/src/nautilus-python.c b/src/nautilus-python.c
+index 843e3c6..466a513 100644
+--- a/src/nautilus-python.c
++++ b/src/nautilus-python.c
+@@ -184,6 +184,9 @@ nautilus_python_init_python (void) {
+         return FALSE;
+     }
+ 
++    debug("Add PyGObject to path");
++    PyRun_SimpleString("import site;import functools; functools.reduce(lambda k, p: site.addsitedir(p, k), [@pythonPaths@], site._init_pathinfo())");
++
+     /* import gobject */
+     debug("init_pygobject");
+     if (!np_init_pygobject()) {