diff --git a/pkgs/development/python-modules/fusepy/default.nix b/pkgs/development/python-modules/fusepy/default.nix
index 45b708630427..03a5248e8e1a 100644
--- a/pkgs/development/python-modules/fusepy/default.nix
+++ b/pkgs/development/python-modules/fusepy/default.nix
@@ -1,4 +1,5 @@
 { lib
+, stdenv
 , buildPythonPackage
 , fetchPypi
 , pkgs
@@ -18,7 +19,9 @@ buildPythonPackage rec {
   # No tests included
   doCheck = false;
 
-  patchPhase = ''
+  # On macOS, users are expected to install macFUSE. This means fusepy should
+  # be able to find libfuse in /usr/local/lib.
+  patchPhase = lib.optionalString (!stdenv.isDarwin) ''
     substituteInPlace fuse.py --replace \
       "find_library('fuse')" "'${pkgs.fuse}/lib/libfuse.so'"
   '';