diff --git a/pkgs/development/interpreters/python/cpython/2.7/default.nix b/pkgs/development/interpreters/python/cpython/2.7/default.nix
index de980f1ca687..e6b3dff433b3 100644
--- a/pkgs/development/interpreters/python/cpython/2.7/default.nix
+++ b/pkgs/development/interpreters/python/cpython/2.7/default.nix
@@ -234,9 +234,6 @@ in with passthru; stdenv.mkDerivation ({
         ln -s $out/lib/${libPrefix}/pdb.py $out/bin/pdb${sourceVersion.major}.${sourceVersion.minor}
         ln -s $out/share/man/man1/{python2.7.1.gz,python.1.gz}
 
-        # Python on Nix is not manylinux1 compatible. https://github.com/NixOS/nixpkgs/issues/18484
-        echo "manylinux1_compatible=False" >> $out/lib/${libPrefix}/_manylinux.py
-
         rm "$out"/lib/python*/plat-*/regen # refers to glibc.dev
 
         # Determinism: Windows installers were not deterministic.
diff --git a/pkgs/development/interpreters/python/cpython/default.nix b/pkgs/development/interpreters/python/cpython/default.nix
index 43d2d159e36a..e75bd0a09875 100644
--- a/pkgs/development/interpreters/python/cpython/default.nix
+++ b/pkgs/development/interpreters/python/cpython/default.nix
@@ -208,9 +208,6 @@ in with passthru; stdenv.mkDerivation {
 
     ln -s "$out/include/${executable}m" "$out/include/${executable}"
 
-    # Python on Nix is not manylinux1 compatible. https://github.com/NixOS/nixpkgs/issues/18484
-    echo "manylinux1_compatible=False" >> $out/lib/${libPrefix}/_manylinux.py
-
     # Determinism: Windows installers were not deterministic.
     # We're also not interested in building Windows installers.
     find "$out" -name 'wininst*.exe' | xargs -r rm -f
diff --git a/pkgs/development/interpreters/python/pypy/default.nix b/pkgs/development/interpreters/python/pypy/default.nix
index 8154a87f667d..b220bfa0f934 100644
--- a/pkgs/development/interpreters/python/pypy/default.nix
+++ b/pkgs/development/interpreters/python/pypy/default.nix
@@ -137,9 +137,6 @@ in with passthru; stdenv.mkDerivation rec {
     # verify cffi modules
     $out/bin/${executable} -c ${if isPy3k then "'import tkinter;import sqlite3;import curses;import lzma'" else "'import Tkinter;import sqlite3;import curses'"}
 
-    # Python on Nix is not manylinux1 compatible. https://github.com/NixOS/nixpkgs/issues/18484
-    echo "manylinux1_compatible=False" >> $out/lib/${libPrefix}/_manylinux.py
-
     # Include a sitecustomize.py file
     cp ${../sitecustomize.py} $out/lib/${libPrefix}/${sitePackages}/sitecustomize.py
   '';