diff --git a/pkgs/development/ruby-modules/gem-config/default.nix b/pkgs/development/ruby-modules/gem-config/default.nix
index 6f9da13f5034..5a6d885159a5 100644
--- a/pkgs/development/ruby-modules/gem-config/default.nix
+++ b/pkgs/development/ruby-modules/gem-config/default.nix
@@ -321,8 +321,12 @@ in
       substituteInPlace Makefile \
         --replace '-Wno-invalid-source-encoding' ""
     '' + lib.optionalString stdenv.isDarwin ''
+      # For < v1.48.0
       substituteInPlace src/ruby/ext/grpc/extconf.rb \
         --replace "ENV['AR'] = 'libtool -o' if RUBY_PLATFORM =~ /darwin/" ""
+      # For >= v1.48.0
+      substituteInPlace src/ruby/ext/grpc/extconf.rb \
+        --replace 'apple_toolchain = ' 'apple_toolchain = false && '
     '';
   };