diff --git a/nixos/doc/manual/release-notes/rl-2405.section.md b/nixos/doc/manual/release-notes/rl-2405.section.md
index b347992031d9..0e43e03f51a2 100644
--- a/nixos/doc/manual/release-notes/rl-2405.section.md
+++ b/nixos/doc/manual/release-notes/rl-2405.section.md
@@ -111,6 +111,8 @@ The pre-existing [services.ankisyncd](#opt-services.ankisyncd.enable) has been m
 
 - `libass` now uses the native CoreText backend on Darwin, which may fix subtitle rendering issues with `mpv`, `ffmpeg`, etc.
 
+- [Lilypond](https://lilypond.org/index.html) and [Denemo](https://www.denemo.org) are now compiled with Guile 3.0.
+
 - The following options of the Nextcloud module were moved into [`services.nextcloud.extraOptions`](#opt-services.nextcloud.extraOptions) and renamed to match the name from Nextcloud's `config.php`:
   - `logLevel` -> [`loglevel`](#opt-services.nextcloud.extraOptions.loglevel),
   - `logType` -> [`log_type`](#opt-services.nextcloud.extraOptions.log_type),
diff --git a/pkgs/applications/audio/denemo/default.nix b/pkgs/applications/audio/denemo/default.nix
index 80018ecc395b..ed4460a28322 100644
--- a/pkgs/applications/audio/denemo/default.nix
+++ b/pkgs/applications/audio/denemo/default.nix
@@ -1,7 +1,8 @@
-{ lib, stdenv, fetchurl, pkg-config
-, libjack2, gettext, intltool, guile_2_2, lilypond
+{ lib, stdenv, fetchurl, fetchpatch, pkg-config
+, libjack2, gettext, intltool, guile, lilypond
 , glib, libxml2, librsvg, libsndfile, aubio
 , gtk3, gtksourceview, evince, fluidsynth, rubberband
+, autoreconfHook, gtk-doc
 , portaudio, portmidi, fftw, wrapGAppsHook }:
 
 stdenv.mkDerivation rec {
@@ -13,8 +14,21 @@ stdenv.mkDerivation rec {
     sha256 = "sha256-S+WXDGmEf5fx+HYnXJdE5QNOfJg7EqEEX7IMI2SUtV0=";
   };
 
+  patches = [
+    (fetchpatch {
+      name = "allow-guile-3.patch";
+      url = "https://git.savannah.gnu.org/cgit/denemo.git/patch/?id=9de1c65e56a021925af532bb55336b0ce86d3084";
+      postFetch = ''
+        substituteInPlace $out \
+          --replace "2.6.8" "2.6.0" \
+          --replace "2.6.9" "2.6.0"
+      '';
+      hash = "sha256-Jj33k/KgvZgKG43MuLgjb4A2KNkm/z9ytzGKcXMAOI4=";
+    })
+  ];
+
   buildInputs = [
-    libjack2 guile_2_2 lilypond glib libxml2 librsvg libsndfile
+    libjack2 guile lilypond glib libxml2 librsvg libsndfile
     aubio gtk3 gtksourceview evince fluidsynth rubberband portaudio fftw portmidi
   ];
 
@@ -25,6 +39,8 @@ stdenv.mkDerivation rec {
   '';
 
   nativeBuildInputs = [
+    autoreconfHook
+    gtk-doc
     wrapGAppsHook
     intltool
     gettext
diff --git a/pkgs/misc/lilypond/default.nix b/pkgs/misc/lilypond/default.nix
index c85f956e1a8b..5fa5e75a637d 100644
--- a/pkgs/misc/lilypond/default.nix
+++ b/pkgs/misc/lilypond/default.nix
@@ -1,4 +1,4 @@
-{ stdenv, lib, fetchurl, ghostscript, gyre-fonts, texinfo, imagemagick, texi2html, guile_2_2
+{ stdenv, lib, fetchurl, ghostscript, gyre-fonts, texinfo, imagemagick, texi2html, guile
 , python3, gettext, flex, perl, bison, pkg-config, autoreconfHook, dblatex
 , fontconfig, freetype, pango, fontforge, help2man, zip, netpbm, groff
 , freefont_ttf, makeFontsConf
@@ -40,7 +40,7 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = [ autoreconfHook bison flex makeWrapper pkg-config ];
 
   buildInputs =
-    [ ghostscript texinfo imagemagick texi2html guile_2_2 dblatex tex zip netpbm
+    [ ghostscript texinfo imagemagick texi2html guile dblatex tex zip netpbm
       python3 gettext perl fontconfig freetype pango
       fontforge help2man groff t1utils boehmgc rsync
     ];