diff --git a/pkgs/development/python-modules/pyrfxtrx/default.nix b/pkgs/development/python-modules/pyrfxtrx/default.nix
new file mode 100644
index 000000000000..6b63ac8f9fe2
--- /dev/null
+++ b/pkgs/development/python-modules/pyrfxtrx/default.nix
@@ -0,0 +1,33 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, pyserial
+, pytestCheckHook
+}:
+
+buildPythonPackage rec {
+  pname = "pyrfxtrx";
+  version = "0.27.0";
+
+  src = fetchFromGitHub {
+    owner = "Danielhiversen";
+    repo = "pyRFXtrx";
+    rev = version;
+    sha256 = "0nzgy56b2v3bnn9idlb67qkzj4cj5j9v1436ri1y305fqwjy48nm";
+  };
+
+  propagatedBuildInputs = [
+    pyserial
+  ];
+
+  checkInputs = [
+    pytestCheckHook
+  ];
+
+  meta = with lib; {
+    description = "Library to communicate with the RFXtrx family of devices";
+    homepage = "https://github.com/Danielhiversen/pyRFXtrx";
+    license = licenses.lgpl3Plus;
+    maintainers = with maintainers; [ dotlambda ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 3a508c692953..64d825ebdfc9 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -5341,6 +5341,8 @@ in {
 
   pynx584 = callPackage ../development/python-modules/pynx584 { };
 
+  pyrfxtrx = callPackage ../development/python-modules/pyrfxtrx { };
+
   pyrogram = callPackage ../development/python-modules/pyrogram { };
 
   pysbd = callPackage ../development/python-modules/pysbd { };